In 1993, Yonsei University Health System (YUHS) initiated medical missionary activities for Mongolia in celebration of the centennial anniversary of the arrival in Korea of Dr. Oliver Avison, the founder of this medical college.

YUHS established a sisterhood relationship with Mongolia National Medical College on March 24, 2003, and formed an agreement to hold scientific interchanges, medical support and medical seminars. Since then, YUHS has been continuing with the operation of various programs including a professor exchange program of the medical school, Mongolian professor training-program, medical consultation services, and the opening of a friendship hospital, Yonsei Memorial Library, central laboratory, and Lee Tae-joon memorial park. In January 2001, a proposal associated with the establishment of the medical missionary work center was passed by the foundation board of directors and this center started functioning as a regular organization to take full charge of all medical missionary activities in March of that year.